IgEhi Endophenotype in Those with Transient Desensitization after Peanut Oral Immunotherapy
نویسندگان
چکیده
منابع مشابه
Successful oral desensitization for systemic peanut allergy.
To the Editor: The present strategy of avoidance and epinephrine autoinjection for severe IgE-mediated food reactions is not always successful.1,2 This may be even truer for young children, who cannot read and have to depend on adults to administer the epinephrine. The following case report illustrates such a failure in a young child and describes a treatment that can be performed by an allergy...
متن کاملPeanut immunotherapy
Peanut allergy is common and can be a cause of severe, life-threatening reactions. It is rarely outgrown like other food allergies, such as egg and milk. Peanut allergy has a significant effect on the quality of life of sufferers and their families, due to dietary and social restrictions, but mainly stemming from fear of accidental peanut ingestion. The current management consists of strict avo...
متن کاملThe safety of peanut oral immunotherapy in peanut-allergic subjects in a single-center trial.
BACKGROUND Peanut allergy is the leading cause of food-related anaphylaxis, and accidental exposures are common. Oral immunotherapy (OIT) has been posited as a potential treatment. METHODS Patients aged 3-65 years with peanut-specific IgE ≥7 kU/l and/or a positive skin prick test with a history of an allergic reaction to peanut were recruited to undergo an OIT protocol. All adverse reactions ...
متن کاملSustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy.
BACKGROUND Although peanut oral immunotherapy (OIT) has been conclusively shown to cause desensitization, it is currently unknown whether clinical protection persists after stopping therapy. OBJECTIVE Our primary objective was to determine whether peanut OIT can induce sustained unresponsiveness after withdrawal of OIT. METHODS We conducted a pilot clinical trial of peanut OIT at 2 US cente...
متن کاملPeanut oral immunotherapy is not ready for clinical use.
Hippocrates wrote that ‘‘The physician must . . . have two special objects in view with regard to disease, namely, to do good or to do no harm’’ (Hippocratic Corpus, Epidemics, Bk I, Sect 5). As physicians, we are continually challenged with the task of weighing the possible risks and benefits of treatment against those of taking no action. Similarly, we pursue clinical investigation when exist...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2018.12.257